Marijuana smoking can lead to abdominal pregnancy or miscarriage

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Smoking marijuana shortly before or soon after conception prevents to ovoimplantation in uterus and can lead to abdominal pregnancy or miscarriage, Journal of Clinical Investigation warns


Smoking
marijuana shortly before or soon after conception prevents to
ovoimplantation in uterus and can lead to abdominal pregnancy or
miscarriage, Journal of Clinical Investigation warns. 

Normally, after conception embryo starts moving along the tube
towards uterus. Coming to its cavity, it is implanted into a mucous
membrane. General ingredient of marijuana - tetrahydrocannabinol (THC)
breaks this process, as scientists from Vanderbilt University
discovered after they carried out experiments on mice.

During experiments Haibin Wang and his colleagues injected mice
with different substances - THC, other components of marijuana, or
placebo - during 4-5 days. Preparations were injected during a period
between conception and implantation of embryo into endometrium.
 
Results of the research showed that ovoimplantation wasn`t
successful in any female. Conception wasn`t broken in animals, which
were injected with other substances or placebo, scientists informed.
 
According to researches, ability of THC to interact with receptors
CB1 and CB2, which are present in different cells of human organism,
and also embryo, underlies in this process.
 
While normal conception a substance - anandamide, formed in a
female organism, fastens to embryo`s CB1 and CB2 receptors. When THC in
injected, it is connected with these receptors, replacing anandamide.
As a result, excess quantity of free anandamide is accumulated in
organism. Excess of this substance breaks normal development of embryo,
its transport and implantation into endometrium. As a result, abdominal
pregnancy can appear, when embryo is developed not in uterus, but in
tune or ovaries.
 
This condition is very dangerous and requires urgent surgical operation, as it
can be complicated with excessive bleeding. 

Regardless of the fact, that experiments were carried out on
animals, their results “is of great clinical importance” for women.
Future investigations will show, whether such process is observed in
human organism, however scientists warn already now: women, wishing to
conceive, should avoid marijuana.



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